Research areas:

Scientific coordinator:

Consiglio Nazionale delle Ricerche (IT)
Università degli Studi di Milano-Bicocca (IT)
Fundacion Tecnalia Research & Innovation (ES)
Acondicionamiento Tarrasense Associacion (ES)
CentiTVC – Centro de Nanotecnalia e Materials Tecnicos Funcionais e Inteligentes Associacao (PT)
Transgero Limited (IT)
University of Limerick (IR)
Commissariat a l’Energie Atomique et Aux Energies Alternatives (FR)
UK Centre for Ecology & Hydrology (UK)
P roject SAS di Massimo Perucca (IT)
Ente Nazionale Italiano di Unificazione (IT)
Colorobbia Consulting (IT)
Wiva Group SPA (IT)
Micananotech Limited (IR)
Bionanoplus SL (ES)
Red of View SRL (IT)
Koivisto Antti Joonas (FI)
Warrant HUB SPA (IT)
Angel Consulting SAS di Matteo Zanotti Russo & C (IT)
Iowa State University of Science and Technology (USA)
University Of Massachusetts (USA)
Peta International Science Consortium Limited (UK)

Type: H2020

End date: 2024

Start date: 2020

Duration: 48

Overall budget: € 5.998.386,06

Funding: € 5.998.386,06

CNR cost: € 1.220.986,25

CNR funding: € 1.220.986,25

STIIMA budget: 189.333,75 €

STIIMA funding: 189.333,75 €

Anticipating Safety Issues at the Design Stage of NAno Product Development

ASINA aims to develop design strategies for the formulation of intrinsically safe nanotechnological products and processes (safe-by-design strategies, SbD). In particular, it focuses on two representative categories of products and related processes: 1) nanostructured coatings for the abatement of organic and biological pollutants, conveyed by environmental vectors, such as water and air; 2) micro/nano-encapsulation systems for the transport of anti-aging and antimicrobial active ingredients, in cosmetic applications. ASINA project adopts an industrial methodology for the improvement of quality and safety of the proposed products/processes, according to a sequence of steps that it envisages:
• DEFINITION: formulation of process and product hypotheses
• MEASURE: measurement of technical and functional performance of the product and assessment of its impact on human health and on the environment during the life cycle of the products
• ANALYSIS: analysis of characterization factors such as the chemical-physical properties of the materials/products and of the process parameters and correlation with the response functions (performance, cost, and safety)
• DESIGN: development of product/process design alternatives, based on previous answers and identification of the most promising strategies
• VERIFY: scale-up of the proposed solutions, with implementation on a pilot scale and adaptation to regulatory requirements
CNR-ISTEC is the Project Coordinator. CNR-STIIMA is involved for the characterization of the antibacterial properties of fabrics and other coated substrates; CNR-ISAC is involved for the characterization of the inhalable fraction of nanoparticles, potentially released during the production and use of products “nano-enabled”.

Key research outcomes:

  • M. Blosi, A. L. Costa, S. Ortelli, F. Belosi, F. Ravegnani, A. Varesano, C. Tonetti, I. Zanoni, C. Vineis, “Polyvinyl alcohol/silver electrospun nanofibers: Biocidal filter media capturing virus-size particles”, Journal of Applied Polymer Science 138(46), 2021, e51380.
  • V. Cazzagon, E. Giubilato, A. Bonetto, M. Blosi, I. Zanoni, A.L. Costa, C. Vineis, A. Varesano, A. Marcomini, D. Hristozov, E. Semenzin, E. Badetti,  “Identification of the Safe(r) By Design alternatives for nanosilver- enabled wound dressings” Frontiers in bioengineering and biotechnology, 10, 987650, 2022 (DOI:10.3389/fbioe.2022.987650)
  • A.L. Costa, M. Blosi, A. Brigliadori, I. Zanoni, S. Ortelli, F. Simeone, S. Delbue, S. D’Alessandro, S. Parapini, C. Vineis, A. Varesano, M. Toprak, B. Hamawandi, D. Gardini, “Eco design for Ag-based solutions against SARS-CoV-22 and E. Coli” Environmental Science: Nano, 2022,